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Tag Archives: diabetes
Spring Book Giveaway: Winner Selected!
By Diane Fennell
The winner of our Diabetes Self-Management book giveaway has been randomly selected (via the number generator at Random.org) and notified by e-mail, so check your inbox to see if you’ve won!
If you were not selected to receive the free copy, you can purchase Best-Ever Tips by calling (800) 664-9269.
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Copyright (C) 2012 R.A. Rapaport Publishing, Inc. All Rights Reserved. See http://www.DiabetesSelfManagement.com/Terms/ for terms and conditions of reuse.
I am little confused with my pregnant GF.?
I am 40 and my GF is 33. We have now been together for 7 months, after 3 months of seeing each other the uh oh happened she got pregnant. Neither one of us wanted anymore kids I have 2 and she has 1, but it happen and she is now 20 weeks and it’s [...]
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2007 Advance Auto Parts “Race for the Cure” Campaign Video
The 2007 Advance Auto Parts “Race for the Cure” Campaign Video for Juvenile Diabetes Research Foundation
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New Erectile Dysfunction Drug Approved
By Diane Fennell
On April 27, pharmaceutical manufacturer Vivus announced the approval of its erectile dysfunction (ED) drug, Stendra (generic name avanafil) by the US Food and Drug Administration. It is the first ED medicine to be approved in over a decade, joining Viagra (sildenafil), Cialis (tadalafil), and Levitra (vardenafil) in the drug class known as phosphodiesterase type 5 inhibitors, or PDE5 inhibitors. Roughly 30 million men in the United States are affected by erectile dysfunction, and according to at least one estimate, over 50% of men will develop ED within 10 years of developing diabetes.
The body produces a chemical called cGMP during sexual stimulation, which causes the blood vessels in the penis to dilate, resulting in an erection. cGMP is broken down by an enzyme known as phosphodiesterase-5 (PDE5). PDE5 inhibitors work by blocking the action of this enzyme, causing levels of cGMP to increase and leading to a better erection.
The safety and effectiveness of Stendra was established through three double-blind, placebo-controlled trials that involved a total of 1,267 people assigned to take Stendra for as long as 12 weeks. The medicine — which may be an option for men who do not respond to Viagra, Cialis, or Levitra — will be available in 50-milligram, 100-milligram, and 200-milligram doses and should be taken 30 minutes before sexual activity at the lowest dose necessary to be effective. According to the drug maker, Stendra may work faster for some men than other medicines in its class, potentially becoming effective in as little as 15 minutes. The medicine should not be taken more than once per day.
“This approval expands the available treatment options to men experiencing erectile dysfunction, and enables patients, in consultation with their doctor, to choose the most appropriate treatment for their needs,” noted Victoria Kusiak, MD, of the FDA’s Center for Drug Evaluation and Research.
Stendra, along with all other medicines in the PDE5 inhibitor class, should not be taken by men who are taking nitrates, as the combination could cause a sudden drop in blood pressure. The most common side effects of Stendra include redness of the face and other areas, headache, nasal congestion, cold-like symptoms, and back pain. In rare cases, taking this drug can lead to an erection that lasts four or more hours. If this occurs, seek medical attention immediately. The drug can also rarely cause decreases in vision or hearing. Anyone experiencing this should stop taking PDE5 inhibitors and call a doctor immediately.
For more information about Stendra, see the article “FDA Approves New Impotence Drug Stendra,” read the press release on the Vivus Web site, or see Stendra’s official Web site.
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Copyright (C) 2012 R.A. Rapaport Publishing, Inc. All Rights Reserved. See http://www.DiabetesSelfManagement.com/Terms/ for terms and conditions of reuse.
New Study Discovers Cause of Pain in Diabetic Neuropathy
Diabetic
neuropathy, or nerve damage, is one of the most painful complications faced
by people with diabetes. Over time, high
blood sugar associated with diabetes may lead to nerve damage. In the legs and feet, this nerve damage
frequently results in numbness or lack of sensation, but it can also lead to
intense pain. Until now, researchers
have not understood exactly why nerve disease leads to this pain, which is difficult
to treat and can negatively affect a person’s quality of life.
Now, a new study has discovered one cause of pain for people
with nerve damage from diabetes. The results
of the study, funded in part by JDRF through a center
grant and conducted by an international collaboration of researchers
including Dr.
Michael Brownlee and the late Dr. Angelika Bierhaus,
were published in the journal Nature Medicine. In the study, conducted in mice, the researchers
found that a molecule called methylglyoxal (MG), which is produced
excessively from glucose in people with diabetes, contributes to the pain. In the mice in the study, the excess MG bound
to a protein called Nav 1.8, which is found in a specific type of nerve cell
responsible for the sensation of pain.
When this bond occurs, the nerve becomes locked in the “on” position,
resulting in the feeling of pain that accompanies nerve damage in people with
diabetes.
Since researchers now better understand what causes the
severe pain associated with diabetic neuropathy, they can use that knowledge to
develop new treatments. According to Dr.
Brownlee, the study “opens the way for new diabetic neuropathy treatments
targeting methylglyoxal accumulation.”
One possible approach is to regulate an enzyme called glyoxalase 1,
which may be able to prevent or remove the modifications caused by MG and
therefore eliminate the pain. According
to Dr. Helen Nickerson, JDRF’s senior scientific program manager for treatment
therapies, “better understanding the role of methyglyoxal could lead to
potential therapy for more than one complication of diabetes.”
This study highlights one of the approaches JDRF is taking
in its research strategy
to prevent complications. This
approach is to identify pathways triggered by high glucose levels over time
that eventually lead to complications, and attempt to intervene in the process
as early as possible to prevent them.
Rebecca!!! Herbs for Voice Quality for you. © Pankaj Oudhia
This film strip was prepared during Pankaj Oudhia’s surveys. For details please visit pankajoudhia.com Related Topics in pankajoudhia.com Anogeissus latifolia in पत्रज+चीता+लौटक+काला अगर based Traditional Herbal Formulations for Diabetes Complications (Pankaj Oudhia’s Medicinal Plant Database), Antiaris toxicaria in पाठा लोटक+ समुद्रफेन+हाउ बेर+तिलका based Traditional Herbal Formulations for Diabetes Complications (Pankaj Oudhia’s Medicinal Plant Database), Antidesma [...]
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Diabetes Population May Rise To 53 Million Within 13 Years In USA
By the year 2025, researchers predict that 53.1 million individuals in the United States will have diabetes (mainly type 2 diabetes) – a 64% increase from 2010. The study is published in Population Health Management Diabetes is a life long disease in which there are high levels of glucose in the blood…
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Molecule That Prevents Heart Damage is Also Proving Its Worth In Diabetic Patients
ACE2, a molecule that has been shown to prevent damage in the heart, is now proving to be protective of the major organs that are often damaged in diabetic patients. Gavin Oudit, a researcher with the Faculty of Medicine & Dentistry, and his colleagues at the University of Florida, found that lab models that lacked ACE2 had worse cardiovascular complications related to diabetes…
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Cheap New Paper-Based Diagnostic Test For Diabetes
With epidemics of Type 2 diabetes looming in rural India, China and other areas of the world where poverty limits the availability of health care, scientists are reporting development of an inexpensive and easy-to-use urine test ideally suited for such areas…
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2008-07-30 A’s Game MUG Root Beer Float Day
A’s MUG Root Beer Float Day set for Wednesday, July 30 A’s players and Bay Area celebrities to scoop ice cream for Juvenile Diabetes Research Foundation OAKLAND — The Oakland Athletics will host its Ninth Annual MUG Root Beer Float Day at McAfee Coliseum on Wednesday, July 30, as the A’s meet the Kansas City [...]
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